indium 111 pharmacology

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Octreoscan (Indium In-111 Pentetreotide) - Uses, Dose ...

Mechanism of action of Indium In-111 pentetreotide (OctreoScan): Pentetreotide, a human hormone somatostatin analog peptide analog, is labeled using the radiopharmaceutical agent Indium 111. It binds to the somatostain 2 receptors. Patients with an increase in insulinoma's signal uptake are likely to have a neuroendocrine tumor.

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Indium In-111: Uses, Interactions, Mechanism of Action ...

20-10-2016· Weight Average: 110.9051 Monoisotopic: 110.905110677 Chemical Formula In Synonyms. Indium (111 In) Pharmacology Indication. Not Available

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Indium-111 - Wikipedia

Indium-111 of 111 In is een onstabiele radioactieve isotoop van indium, een hoofdgroepmetaal.De isotoop komt van nature niet op Aarde voor.. Indium-111 ontstaat onder meer bij het radioactief verval van tin-111.. Radioactief verval. Indium-111 vervalt door elektronenvangst tot de stabiele isotoop cadmium-111: + + ¯ De halveringstijd bedraagt 2,8 dagen.

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Indium-111 - Wikipedia

Indium-111 (111 In) is a radioactive isotope of indium (In). It decays by electron capture to stable cadmium-111 with a half-life of 2.8 days. Indium-111 chloride (111 InCl) solution is produced by proton irradiation of a cadmium target (112 Cd(p,2n) or 111 Cd(p,n)) in a cyclotron, as recommended by International Atomic Energy Agency (IAEA).The former method is more commonly used as it results ...

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indium in-111 oxyquinoline Clinical Pharmacology Drug ...

Drug monographs for indium in-111 oxyquinoline provide an overview of the drug product, therapeutic uses, key development issues, regulatory information, and therapeutic classifications on …

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INDIUM (111 IN) OXINE SOLUTION (Indium 111-IN OXINE)

INDIUM In-111 OXINE SOLUTION THERAPEUTIC OR PHARMACOLOGICAL CLASSIFICATION Radiodiagnostic Agent (For Radiolabelling Autologous Leukocytes) DESCRIPTION Indium In-111 oxine is a diagnostic radiopharmaceutical intended for radiolabelling autologous leukocytes. It is supplied as a sterile, non-pyrogenic, isotonic aqueous solution with a pH range

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Indium In 111 Daclizumab (Concept Id: C4764300)

A radioimmunoconjugate comprised of daclizumab, a recombinant humanized monoclonal antibody directed against the alpha subunit of the interleukin-2 (IL-2) receptor (IL-2RA, TAC antigen, CD25), which is labeled with the gamma-emitting isotope indium 111 (In 111; 111In), with potential radioimaging application. Upon administration, indium In 111 daclizumab targets and binds to IL-2RA and ...

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Kit for the Preparation of Indium In 111 Pentetreotide

indium In-111 pentetreotide is not expected to exert clinically significant somatostatin effects. Indium In-111 pentetreotide is cleared from the body primarily by renal excretion. Indium In-111 pentetreotide elimination has not been studied in anephric patients or in those with poorly functioning kidneys. It is not known whether indium In-111

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Indium In 111 chloride | Cl3In - PubChem

Indium In-111 Chloride is a radioactive salt that is used as a reagent in the preparation of indium 111-labeled radiopharmaceuticals. Indium 111-labeled radioconjugates are used as radioactive tracers in nuclear medicine that detect malignant lesions and inflammatory tissues probably due to an increased capillary permeability. Indium-111 chloride is particularly used in the radiolabeling of ...

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Indium in 111 Oxyquinoline Pharmacological Profile ...

Pharmacology refers to the chemical makeup and behavior of INDIUM IN 111 OXYQUINOLINE (indium in-111 oxyquinoline solution).

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indium in-111 dtpa Clinical Pharmacology Drug Monograph

Drug monographs for indium in-111 dtpa provide an overview of the drug product, therapeutic uses, key development issues, regulatory information, and therapeutic classifications on ScriptSave WellRx.

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Indium 111 - an overview | ScienceDirect Topics

Indium 111. 111 In discussing racial and ethnic differences in serum vitamin D levels and BMD, Dawson-Hughes113 concluded that for improved bone health the serum 25-hydroxy vitamin D level should be 80nmol/liter, and to achieve that concentration, 800–1000IU/day of vitamin D is required, regardless of race and ethnicity.

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INDIUM IN-111 OXYQUINOLINE Solution for injection - RxReasoner

The human biodistribution studies in three normal subjects injected with indium In-111 oxyquinoline labeled leukocytes indicate a biexponential disappearance of indium In-111 from the blood when monitored for up to 72 hours. Between 9.5 to 24.4% of the injected dose remains in whole blood and clears with a biological half-time of 2.8 to 5.5 hours.

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8 Quinolinol Indium in 111 - an overview | ScienceDirect ...

111 In-oxine is lipophilic in nature and passively diffuses into cells. Once inside the cell the indium-111 stably binds to the intracellular compounds and integrates the isotope inside the cell [118]. 111 In-oxine has a half-life of 2.8 days allowing for imaging of labeled cells for up to 14 days [119].

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Indium-111–Pentetreotide Scintigraphy and Somatostatin ...

Pharmacology, University of Wurzburg, Wurzburg, Germany. Submitted May 31, 2007; accepted October 30, 2007. Supported by grants from Groupe de Recherche de l'Institut Claudius Re´gaud, ... receptor scintigraphy using indium-111–pentetreotide (111In-pentetreotide) and for medical treat-ment.

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Indium In-111 oxyquinoline: Uses, Interactions, Mechanism ...

30-11-2015· Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detected with a gamma ray camera.

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Indium (111 Oxyquinoline): Uses, Dosage, Side Effects ...

28-02-2019· Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling autologous leukocytes. It is supplied as a sterile, non-pyrogenic, isotonic aqueous solution with a pH range of 6.5 to 7.5. Each mL of the solution contains 37 MBq, 1 mCi of indium In 111 [no carrier added, >1.85 GBq/μg indium (>50 mCi/μg indium ...

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Indium DTPA In 111 Pharmacological Profile | Healthgrades ...

Pharmacology refers to the chemical makeup and behavior of INDIUM DTPA IN 111 (indium in-111 pentetate disodium solution).

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Indium oxyquinoline - wikidoc

Indium In 111 oxyquinoline solution should be stored at room temperature (15-25°C, 59-77°F). Indium In 111 oxyquinoline labeled autologous leukocytes should preferably be …

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Indium IN-111 pentetate disodium | C14H18InN3Na2O10 - …

CID 3053 (Pentetic acid) Date s. Modify. . Create. . Indium in-111 pentetate disodium is a Radioactive Diagnostic Agent. The mechanism of action of indium in-111 pentetate disodium is as a Radiopharmaceutical Activity. FDA Pharm Classes.

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Indium In 111 Oxyquinoline - Uses, MOA, Dose, Side effects

Contraindications to Indium In-111 oxyquinoline:. There are no contraindications listed within the manufacturer's labeling. Warnings and Precautions. Leukopenia: Autologous leukocyte labeling is not recommended in patients with leukopenia because of the small number of leukocytes that may result in a false-negative report.

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INDIUM DTPA In 111 - Radio Rx

INDIUM DTPA In 111 PENTETATE INDIUM DISODIUM In 111 DESCRIPTION GE Healthcare (Medi-Physics, Inc.) Indium DTPA In 111 is a diagnostic drug for intrathecal use. It is available as a sterile, pyrogen-free, isotonic, aqueous solution, buffered to pH 7 to 8. At calibration time, each milliliter contains 37 MBq, 1 mCi of Pentetate Indium Disodium In ...

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HIGH PURITY INDIUM CHLORIDE In 111 STERILE SOLUTION

High Purity Indium In 111 Chloride Sterile Solution for use as a radiolabeling agent, is a sterile, non-pyrogenic (less than 5 endotoxin units/mL), solution of indium 111 chloride (InCl 3) with a pH of 1.1 to 1.4. At the time of calibration, each one-half millilitre contains 185 megabecquerels (5 millicuries) of indium 111 chloride (InCl 3

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Indium In 111 - FDA prescribing information, side effects ...

Indium forms a saturated (1:3) complex with oxyquinoline. The complex is neutral and lipid-soluble, which enables it to penetrate the cell membrane. It is thought likely that the mechanism of labeling cells with indium In-111 oxyquinoline involves an exchange reaction between the oxyquinoline carrier and subcellular components which chelate indium more strongly than oxyquinoline.

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Pharmacokinetics of an indium-111-labeled monoclonal ...

17-07-2021· The authors have evaluated the pharmacokinetics in patients of a monoclonal antibody (19-9) F(ab')/sub 2/ fragment coupled with DTPA and labeled with /sup 111/In. In addition to imaging and organ uptake determinations, serum and urine samples …

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